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Hydrogen-rich water positively affects HOMA2 variables in physically inactive population Darinka Korovljev, Dejan Javorac, Valdemar Stajer, Sergej M. Ostojic Faculty of Sport and Physical Education, University of Novi Sad, Serbia Correspondence: Sergej M. Ostojic ( BMC Sports Science, Medicine and Rehabilitation 2019, 11(Suppl 1):O1 Supplemental molecular hydrogen improves biomarkers of cardiometabolic health in physically active men and women yet no human studies evaluated its effects on steady state beta cell function and insulin sensitivity in non-active humans. PURPOSE: To evaluate the effects of 28- day intake of hydrogen-rich water (HRW) on Homeostasis Model Assessment (HOMA2) outcomes and body composition in a cohort of physically inactive men and women. METHODS: Twelve overweight inactive volunteers (7 women and 5 men; age 56.2 ± 10.0 years; BMI 37.7 ± 5.3 kg/m2 ) participated in this randomized, double-blind, placebocontrolled, crossover trial. Participants were allocated to receive either HRW (1 L/day) or placebo (tap water) for 28 days. HRW was produced by dissolving an effervescent magnesium tablet (HRW Natural Health Products Inc., New Westminster, Canada) into a cup of water (500 mL). RESULTS: Drinking HRW was superior to placebo to increase insulin sensitivity (for up to 11.1%; p < 0.05), and tended to reduce body fat at 28-day follow-up more as compared to placebo (- 4.2% vs. 0.6%; p = 0.09). CONCLUSION: The results of this trial nominate HRW as a possible nutritional strategy to improve insulin sensitivity in overweight inactive population. Registered at (NCT03625362). ACKNOWLEDGMENTS Supported by the Serbian Ministry of Education, Science and Technological Development (175037), the Provincial Secretariat for Higher Education and Scientific Research (114-451-710), the Faculty of Sport and Physical Education, and HRW Natural Health Products Inc.

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